2ntt: Difference between revisions

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[[Image:2ntt.gif|left|200px]]


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==Crystal Structure of SEK==
The line below this paragraph, containing "STRUCTURE_2ntt", creates the "Structure Box" on the page.
<StructureSection load='2ntt' size='340' side='right'caption='[[2ntt]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ntt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.561&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
{{STRUCTURE_2ntt|  PDB=2ntt  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntt OCA], [https://pdbe.org/2ntt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntt RCSB], [https://www.ebi.ac.uk/pdbsum/2ntt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntt ProSAT]</span></td></tr>
 
</table>
'''Crystal Structure of SEK'''
== Function ==
 
[https://www.uniprot.org/uniprot/Q93CC5_STAAU Q93CC5_STAAU]  
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are characterized by the alpha3-beta8 loop, a unique approximately 15 amino acid residue extension that is required for optimal T cell activation. Here, we report the X-ray crystal structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding orientation relative to other SAG-TCR complexes, which results in the alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These interactions are absolutely required for TCR binding and T cell activation by SEK, and dictate the TCR Vbeta domain specificity of SEK and other group V SAGs.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntt_consurf.spt"</scriptWhenChecked>
2NTT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTT OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
A novel loop domain in superantigens extends their T cell receptor recognition site., Gunther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ, J Mol Biol. 2007 Aug 3;371(1):210-21. Epub 2007 May 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17560605 17560605]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ntt ConSurf].
[[Category: Single protein]]
<div style="clear:both"></div>
[[Category: Staphylococcus aureus]]
__TOC__
[[Category: Gunther, S.]]
</StructureSection>
[[Category: Moza, B.]]
[[Category: Large Structures]]
[[Category: Sundberg, E J.]]
[[Category: Staphylococcus aureus subsp. aureus COL]]
[[Category: Varma, A K.]]
[[Category: Gunther S]]
[[Category: Superantigen]]
[[Category: Moza B]]
[[Category: T cell receptor]]
[[Category: Sundberg EJ]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:54:15 2008''
[[Category: Varma AK]]
Retrieved from "https://proteopedia.org/2ntt"