1tgs: Difference between revisions

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New page: left|200px<br /> <applet load="1tgs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tgs, resolution 1.8Å" /> '''THREE-DIMENSIONAL ST...
 
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[[Image:1tgs.gif|left|200px]]<br />
<applet load="1tgs" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1tgs, resolution 1.8&Aring;" />
'''THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION'''<br />


==About this Structure==
==THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION==
1TGS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4 and CA as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1TGS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb46_1.html Trypsin]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TGS OCA].  
<StructureSection load='1tgs' size='340' side='right'caption='[[1tgs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[1tgs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Trypsin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_10 10.2210/rcsb_pdb/mom_2003_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGS FirstGlance]. <br>
Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation., Bolognesi M, Gatti G, Menagatti E, Guarneri M, Marquart M, Papamokos E, Huber R, J Mol Biol. 1982 Dec 25;162(4):839-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7169635 7169635]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgs OCA], [https://pdbe.org/1tgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgs RCSB], [https://www.ebi.ac.uk/pdbsum/1tgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgs ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Trypsin]]
[[Category: Trypsin]]
[[Category: Bolognesi, M.]]
[[Category: Bolognesi M]]
[[Category: Gatti, G.]]
[[Category: Gatti G]]
[[Category: Guarneri, M.]]
[[Category: Guarneri M]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Marquart, M.]]
[[Category: Marquart M]]
[[Category: Menegatti, E.]]
[[Category: Menegatti E]]
[[Category: Papamokos, E.]]
[[Category: Papamokos E]]
[[Category: CA]]
[[Category: SO4]]
[[Category: complex (proteinase/inhibitor)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:06:31 2007''
Retrieved from "https://proteopedia.org/1tgs"