6adh: Difference between revisions

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New page: left|200px<br /> <applet load="6adh" size="450" color="white" frame="true" align="right" spinBox="true" caption="6adh, resolution 2.9Å" /> '''STRUCTURE OF TRICLIN...
 
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[[Image:6adh.gif|left|200px]]<br />
<applet load="6adh" size="450" color="white" frame="true" align="right" spinBox="true"
caption="6adh, resolution 2.9&Aring;" />
'''STRUCTURE OF TRICLINIC TERNARY COMPLEX OF HORSE LIVER ALCOHOL DEHYDROGENASE AT 2.9 ANGSTROMS RESOLUTION'''<br />


==About this Structure==
==STRUCTURE OF TRICLINIC TERNARY COMPLEX OF HORSE LIVER ALCOHOL DEHYDROGENASE AT 2.9 ANGSTROMS RESOLUTION==
6ADH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with ZN, NAD and DMS as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 6ADH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb13_1.html Alcohol Dehydrogenase]]. Active as [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=6ADH OCA].  
<StructureSection load='6adh' size='340' side='right'caption='[[6adh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6adh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. The January 2001 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Alcohol Dehydrogenase''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2001_1 10.2210/rcsb_pdb/mom_2001_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ADH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ADH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6adh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6adh OCA], [https://pdbe.org/6adh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6adh RCSB], [https://www.ebi.ac.uk/pdbsum/6adh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6adh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADH1E_HORSE ADH1E_HORSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/6adh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=6adh ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution., Eklund H, Samma JP, Wallen L, Branden CI, Akeson A, Jones TA, J Mol Biol. 1981 Mar 15;146(4):561-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7024556 7024556]
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Alcohol Dehydrogenase]]
[[Category: Alcohol Dehydrogenase]]
[[Category: Alcohol dehydrogenase]]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Eklund, H.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: DMS]]
[[Category: Eklund H]]
[[Category: NAD]]
[[Category: ZN]]
[[Category: oxidoreductase (nad(a)-choh(d))]]
 
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