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[[Image:2osn.jpg|left|200px]]
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{{STRUCTURE_2osn|  PDB=2osn  |  SCENE=  }}
'''An alternate description of a crystal structure of phospholipase A2 from Bungarus caeruleus'''


==An alternate description of a crystal structure of phospholipase A2 from Bungarus caeruleus==
<StructureSection load='2osn' size='340' side='right'caption='[[2osn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2osn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_caeruleus Bungarus caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osn OCA], [https://pdbe.org/2osn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osn RCSB], [https://www.ebi.ac.uk/pdbsum/2osn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA2B3_BUNCE PA2B3_BUNCE] Snake venom phospholipase A2 (PLA2) that shows anticoagulant and neurotoxic activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2osn ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Reinterpretations of the space-group symmetry are reported for two crystal structures of phospholipase A(2) isoforms (PDB codes 1u4j and 1g2x). The two structures reported in space groups R3 and C2 are isomorphous with a third isoform with space group R32 (PDB code 1fe5). The original structure reports were interpreted in terms of different oligomeric forms of the isoforms, but these conclusions are not supported by the isomorphous structures.


==Overview==
An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus.,Le Trong I, Stenkamp RE Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):548-9. Epub 2007, Mar 16. PMID:17372360<ref>PMID:17372360</ref>
Reinterpretations of the space-group symmetry are reported for two crystal structures of phospholipase A(2) isoforms (PDB codes 1u4j and 1g2x). The two structures reported in space groups R3 and C2 are isomorphous with a third isoform with space group R32 (PDB code 1fe5). The original structure reports were interpreted in terms of different oligomeric forms of the isoforms, but these conclusions are not supported by the isomorphous structures.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2OSN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_caeruleus Bungarus caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSN OCA].
</div>
<div class="pdbe-citations 2osn" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus., Le Trong I, Stenkamp RE, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):548-9. Epub 2007, Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372360 17372360]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bungarus caeruleus]]
[[Category: Bungarus caeruleus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Stenkamp, R E.]]
[[Category: Le Trong I]]
[[Category: Trong, I Le.]]
[[Category: Stenkamp RE]]
[[Category: Krait venom]]
[[Category: Phospholipase]]
[[Category: Structure reinterpretation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:34:36 2008''
Retrieved from "https://proteopedia.org/2osn"