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[[Image:2pl2.jpg|left|200px]]


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==Crystal structure of TTC0263: a thermophilic TPR protein in Thermus thermophilus HB27==
The line below this paragraph, containing "STRUCTURE_2pl2", creates the "Structure Box" on the page.
<StructureSection load='2pl2' size='340' side='right'caption='[[2pl2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PL2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pl2 OCA], [https://pdbe.org/2pl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2pl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pl2 ProSAT]</span></td></tr>
{{STRUCTURE_2pl2|  PDB=2pl2  |  SCENE= }}
</table>
 
== Function ==
'''Crystal structure of TTC0263: a thermophilic TPR protein in Thermus thermophilus HB27'''
[https://www.uniprot.org/uniprot/Q72L02_THET2 Q72L02_THET2]
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The hypothetical protein TTC0263 of Thermus thermophilus HB27 is a thermophilic tetratricopeptide repeat (TPR)-containing protein. In the present study, the TPR region (residues 26-230) was resolved at 2.5 A with R-factors of R/Rfree = 23.6%/28.6%. TTC0263 consists of 11 helices that form five TPR units. Uniquely, it contains one atypical "extended" TPR (eTPR) unit. This comprises extended helical residues near the loop region of TTC0263, such that the helical length of eTPR is longer than that of the canonical TPR sequence. In addition, the hybrid TPR domain of TTC0263 possesses oligomer-forming characteristics. TPR domains are generally involved in forming multi-subunit complexes by interacting with each other or with other subunit proteins. The dynamic structure of TTC0263 described here goes some way to explaining how TPR domains mediate the formation of multi-subunit complexes.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2pl2_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2PL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL2 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pl2 ConSurf].
Crystal structure of TTC0263, a thermophilic TPR protein from Thermus thermophilus HB27., Lim H, Kim K, Han D, Oh J, Kim Y, Mol Cells. 2007 Aug 31;24(1):27-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17846496 17846496]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Thermus thermophilus]]
</StructureSection>
[[Category: Han, D.]]
[[Category: Large Structures]]
[[Category: Kim, K.]]
[[Category: Thermus thermophilus HB27]]
[[Category: Lim, H.]]
[[Category: Han D]]
[[Category: Oh, J.]]
[[Category: Kim K]]
[[Category: Protein binding]]
[[Category: Lim H]]
[[Category: Tpr]]
[[Category: Oh J]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:20:07 2008''

Latest revision as of 13:53, 13 March 2024

Crystal structure of TTC0263: a thermophilic TPR protein in Thermus thermophilus HB27

2pl2, resolution 2.50Å

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