2q1v: Difference between revisions

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[[Image:2q1v.jpg|left|200px]]


<!--
==Ancestral corticoid receptor in complex with cortisol==
The line below this paragraph, containing "STRUCTURE_2q1v", creates the "Structure Box" on the page.
<StructureSection load='2q1v' size='340' side='right'caption='[[2q1v]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2q1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q1V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PDN:17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE'>PDN</scene></td></tr>
{{STRUCTURE_2q1v|  PDB=2q1v  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1v OCA], [https://pdbe.org/2q1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q1v RCSB], [https://www.ebi.ac.uk/pdbsum/2q1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q1v ProSAT]</span></td></tr>
 
</table>
'''Ancestral corticoid receptor in complex with cortisol'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==Overview==
  <jmolCheckbox>
The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucocorticoid (GR) and mineralocorticoid (MR) receptors. Using structural, phylogenetic, and functional analysis, we identify the specific set of historical mutations that recapitulate the evolution of GR's hormone specificity from an MR-like ancestor. These substitutions repositioned crucial residues to create new receptor-ligand and intraprotein contacts. Strong epistatic interactions occur because one substitution changes the conformational position of another site. "Permissive" mutations-substitutions of no immediate consequence, which stabilize specific elements of the protein and allow it to tolerate subsequent function-switching changes-played a major role in determining GR's evolutionary trajectory.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/2q1v_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1V OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q1v ConSurf].
==Reference==
<div style="clear:both"></div>
Crystal structure of an ancient protein: evolution by conformational epistasis., Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW, Science. 2007 Sep 14;317(5844):1544-8. Epub 2007 Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702911 17702911]
__TOC__
[[Category: Ortlund, E A.]]
</StructureSection>
[[Category: Redinbo, M R.]]
[[Category: Large Structures]]
[[Category: Common ancestor]]
[[Category: Unidentified]]
[[Category: Corticoid]]
[[Category: Ortlund EA]]
[[Category: Cortisol]]
[[Category: Redinbo MR]]
[[Category: Evolution]]
[[Category: Mineralocorticoid]]
[[Category: Nuclear receptor]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:11:22 2008''

Latest revision as of 09:13, 21 February 2024

Ancestral corticoid receptor in complex with cortisol

2q1v, resolution 1.95Å

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