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[[Image:2qxw.jpg|left|200px]]
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{{STRUCTURE_2qxw|  PDB=2qxw  |  SCENE=  }}
'''Perdeuterated alr2 in complex with idd594'''


==Perdeuterated alr2 in complex with idd594==
<StructureSection load='2qxw' size='340' side='right'caption='[[2qxw]], [[Resolution|resolution]] 0.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxw OCA], [https://pdbe.org/2qxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qxw RCSB], [https://www.ebi.ac.uk/pdbsum/2qxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qxw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qxw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qxw ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 A, 100K; 0.80 A, 15K; 1.75 A, 293K), neutron Laue data (2.2 A, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and mobility of the hydrogen bond network that defines the properties of the catalytic engine, explaining how this promiscuous enzyme overcomes the simultaneous requirements of efficiency and promiscuity offering a general mechanistic view for this class of enzymes.


==Overview==
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.,Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:18250329<ref>PMID:18250329</ref>
We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 A, 100K; 0.80 A, 15K; 1.75 A, 293K), neutron Laue data (2.2 A, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and mobility of the hydrogen bond network that defines the properties of the catalytic engine, explaining how this promiscuous enzyme overcomes the simultaneous requirements of efficiency and promiscuity offering a general mechanistic view for this class of enzymes.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2QXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA].
</div>
<div class="pdbe-citations 2qxw" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase., Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18250329 18250329]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
[[Category: Aldehyde reductase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Afonine, P.]]
[[Category: Afonine P]]
[[Category: Blakely, M.]]
[[Category: Blakeley MP]]
[[Category: Cachau, R.]]
[[Category: Cachau R]]
[[Category: Cousido-Siah, A.]]
[[Category: Cousido-Siah A]]
[[Category: Ginell, S.]]
[[Category: Ginell S]]
[[Category: Hazemann, I.]]
[[Category: Hazemann I]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Meilleur, F.]]
[[Category: Meilleur F]]
[[Category: Mitschler, A.]]
[[Category: Mitschler A]]
[[Category: Myles, D.]]
[[Category: Myles D]]
[[Category: Podjarny, A.]]
[[Category: Podjarny A]]
[[Category: Ruiz, F.]]
[[Category: Ruiz F]]
[[Category: Ventura, O.]]
[[Category: Ventura O]]
[[Category: Acetylation]]
[[Category: Cataract]]
[[Category: Cytoplasm]]
[[Category: Idd594]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:52:57 2008''
Retrieved from "https://proteopedia.org/2qxw"