2v0f: Difference between revisions

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[[Image:2v0f.gif|left|200px]]
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{{STRUCTURE_2v0f|  PDB=2v0f  |  SCENE=  }}
'''BRK DOMAIN FROM HUMAN CHD7'''


==BRK domain from human CHD7==
<StructureSection load='2v0f' size='340' side='right'caption='[[2v0f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2v0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0F FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ckc|2ckc]], [[2v0e|2v0e]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0f OCA], [https://pdbe.org/2v0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0f RCSB], [https://www.ebi.ac.uk/pdbsum/2v0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0f ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v0f ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.


==Overview==
Solution structure of the BRK domains from CHD7.,Allen MD, Religa TL, Freund SM, Bycroft M J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:17603073<ref>PMID:17603073</ref>
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2V0F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0F OCA].
</div>
<div class="pdbe-citations 2v0f" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Solution structure of the BRK domains from CHD7., Allen MD, Religa TL, Freund SM, Bycroft M, J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17603073 17603073]
*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
[[Category: Homo sapiens]]
*[[Helicase 3D structures|Helicase 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Allen, M D.]]
<references/>
[[Category: Bycroft, M.]]
__TOC__
[[Category: Freund, S M.V.]]
</StructureSection>
[[Category: Religa, T L.]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Allen, M D]]
[[Category: Bycroft, M]]
[[Category: Freund, S M.V]]
[[Category: Religa, T L]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Brk domain]]
[[Category: Brk domain]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:57:30 2008''
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