2v1n: Difference between revisions
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< | ==SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMAN KIN17 REVEALS A WINGED HELIX FOLD== | ||
<StructureSection load='2v1n' size='340' side='right'caption='[[2v1n]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> | |||
You may | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v1n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V1N FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ckk|2ckk]]</div></td></tr> | |||
-- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1n OCA], [https://pdbe.org/2v1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v1n RCSB], [https://www.ebi.ac.uk/pdbsum/2v1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v1n ProSAT]</span></td></tr> | ||
</table> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v1n_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v1n ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human KIN17 is a 45-kDa eukaryotic DNA- and RNA-binding protein that plays an important role in nuclear metabolism and in particular in the general response to genotoxics. Its amino acids sequence contains a zinc finger motif (residues 28-50) within a 30-kDa N-terminal region conserved from yeast to human, and a 15-kDa C-terminal tandem of SH3-like subdomains (residues 268-393) only found in higher eukaryotes. Here we report the solution structure of the region 51-160 of human KIN17. We show that this fragment folds into a three-alpha-helix bundle packed against a three-stranded beta-sheet. It belongs to the winged helix (WH) family. Structural comparison with analogous WH domains reveals that KIN17 WH module presents an additional and highly conserved 3(10)-helix. Moreover, KIN17 WH helix H3 is not positively charged as in classical DNA-binding WH domains. Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. | |||
Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.,Carlier L, Couprie J, le Maire A, Guilhaudis L, Milazzo-Segalas I, Courcon M, Moutiez M, Gondry M, Davoust D, Gilquin B, Zinn-Justin S Protein Sci. 2007 Dec;16(12):2750-5. PMID:18029424<ref>PMID:18029424</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2v1n" style="background-color:#fffaf0;"></div> | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Carlier, L | __TOC__ | ||
[[Category: Couprie, J | </StructureSection> | ||
[[Category: Davoust, D | [[Category: Human]] | ||
[[Category: Gilquin, B | [[Category: Large Structures]] | ||
[[Category: Gondry, M | [[Category: Carlier, L]] | ||
[[Category: Guilhaudis, L | [[Category: Couprie, J]] | ||
[[Category: Maire, A Le | [[Category: Davoust, D]] | ||
[[Category: Milazzo, I | [[Category: Gilquin, B]] | ||
[[Category: Zinn-Justin, S | [[Category: Gondry, M]] | ||
[[Category: Guilhaudis, L]] | |||
[[Category: Maire, A Le]] | |||
[[Category: Milazzo, I]] | |||
[[Category: Zinn-Justin, S]] | |||
[[Category: Kin17]] | [[Category: Kin17]] | ||
[[Category: Nuclear protein]] | [[Category: Nuclear protein]] | ||
[[Category: Winged helix motif]] | [[Category: Winged helix motif]] | ||
Latest revision as of 12:36, 23 March 2022
SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMAN KIN17 REVEALS A WINGED HELIX FOLD
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