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[[Image:365d.gif|left|200px]]


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==STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE==
The line below this paragraph, containing "STRUCTURE_365d", creates the "Structure Box" on the page.
<StructureSection load='365d' size='340' side='right'caption='[[365d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[365d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=365D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=IIP:IMIDAZOLE-PYRROLE+POLYAMIDE'>IIP</scene></td></tr>
{{STRUCTURE_365d|  PDB=365d  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=365d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=365d OCA], [https://pdbe.org/365d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=365d RCSB], [https://www.ebi.ac.uk/pdbsum/365d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=365d ProSAT]</span></td></tr>
 
</table>
'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Baird EE]]
Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.
[[Category: Dervan PB]]
 
[[Category: Kielkopf CL]]
==About this Structure==
[[Category: Rees DC]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA].  
 
==Reference==
Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461074 9461074]
[[Category: Baird, E E.]]
[[Category: Dervan, P B.]]
[[Category: Kielkopf, C L.]]
[[Category: Rees, D C.]]
[[Category: B-dna]]
[[Category: Double helix]]
[[Category: Modified]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:17:29 2008''

Latest revision as of 08:39, 7 February 2024

STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE

365d, resolution 2.00Å

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