1run: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /><applet load="1run" size="450" color="white" frame="true" align="right" spinBox="true" caption="1run, resolution 2.700Å" /> '''CATABOLITE GENE ACT...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(16 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1run.gif|left|200px]]<br /><applet load="1run" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1run, resolution 2.700&Aring;" />
'''CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'''<br />


==About this Structure==
==CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE==
1RUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CMP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RUN OCA].  
<StructureSection load='1run' size='340' side='right'caption='[[1run]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1run]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1run OCA], [https://pdbe.org/1run PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1run RCSB], [https://www.ebi.ac.uk/pdbsum/1run PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1run ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1run_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1run ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Aromatic hydrogen bond in sequence-specific protein DNA recognition., Parkinson G, Gunasekera A, Vojtechovsky J, Zhang X, Kunkel TA, Berman H, Ebright RH, Nat Struct Biol. 1996 Oct;3(10):837-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8836098 8836098]
*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Berman, H.M.]]
[[Category: Berman HM]]
[[Category: Ebright, R.H.]]
[[Category: Ebright RH]]
[[Category: Gunasekera, A.]]
[[Category: Gunasekera A]]
[[Category: Kunkel, T.A.]]
[[Category: Kunkel TA]]
[[Category: Parkinson, G.N.]]
[[Category: Parkinson GN]]
[[Category: Vojtechovsky, J.]]
[[Category: Vojtechovsky J]]
[[Category: Zhang, X.]]
[[Category: Zhang X]]
[[Category: CMP]]
[[Category: transcription regulation; 3d-structure; dna-binding; camp-binding; activator]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:59:48 2007''
Retrieved from "https://proteopedia.org/1run"