4bna: Difference between revisions

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[[Image:4bna.gif|left|200px]]


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==REVERSIBLE BENDING AND HELIX GEOMETRY IN A B-DNA DODECAMER: CGCGAATTBRCGCG==
The line below this paragraph, containing "STRUCTURE_4bna", creates the "Structure Box" on the page.
<StructureSection load='4bna' size='340' side='right'caption='[[4bna]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4bna]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BNA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr>
{{STRUCTURE_4bna|  PDB=4bna  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bna OCA], [https://pdbe.org/4bna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bna RCSB], [https://www.ebi.ac.uk/pdbsum/4bna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bna ProSAT]</span></td></tr>
 
</table>
'''REVERSIBLE BENDING AND HELIX GEOMETRY IN A B-DNA DODECAMER: CGCGAATTBRCGCG'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Dickerson RE]]
A double-helical B-DNA dodecamer has been analyzed by single crystal x-ray diffraction methods and refined independently in four variants: sequence CGCGAATTCGCG at 20 degrees C and at 16 K, and CGCGAATTBrCGCG in 60% methylpentanediol at 20 and at 7 degrees C. The first three forms show a 14-19 degrees bend in overall helix axis, but the fourth is straight and unbent. Detailed comparisons of the various forms have led to a better understanding of helix geometry and bending. Structural principles can be understood best if organized under four headings: 1) intrinsic geometry of the sugar rings, 2) stacking and relative motion of base pairs, 3) geometry of the connecting phosphate backbone, and 4) mechanics of bending in B-DNA. The observed bending is neither completely localized nor smooth and continuous, but an intermediate compromise that can be termed "annealed kinking."
[[Category: Fratini AV]]
 
[[Category: Kopka ML]]
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNA OCA].  
 
==Reference==
Reversible bending and helix geometry in a B-DNA dodecamer: CGCGAATTBrCGCG., Fratini AV, Kopka ML, Drew HR, Dickerson RE, J Biol Chem. 1982 Dec 25;257(24):14686-707. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7174662 7174662]
[[Category: Dickerson, R E.]]
[[Category: Fratini, A V.]]
[[Category: Kopka, M L.]]
[[Category: B-dna]]
[[Category: Double helix]]
[[Category: Modified]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:21:27 2008''

Latest revision as of 10:40, 1 March 2024

REVERSIBLE BENDING AND HELIX GEOMETRY IN A B-DNA DODECAMER: CGCGAATTBRCGCG

4bna, resolution 2.30Å

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