2jsf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_2jsf", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2jsf.jpg|left|200px]]


<!--
==Solution structures of the envelope protein domain III from the dengue-2 virus==
The line below this paragraph, containing "STRUCTURE_2jsf", creates the "Structure Box" on the page.
<StructureSection load='2jsf' size='340' side='right'caption='[[2jsf]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsf OCA], [https://pdbe.org/2jsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsf RCSB], [https://www.ebi.ac.uk/pdbsum/2jsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsf ProSAT]</span></td></tr>
{{STRUCTURE_2jsf|  PDB=2jsf  |  SCENE= }}
</table>
 
== Function ==
'''Solution structures of the envelope protein domain III from the dengue-2 virus'''
[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).  Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
 
__TOC__
 
</StructureSection>
==About this Structure==
2JSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSF OCA].  
 
==Reference==
Solution structure and neutralizing antibody binding studies of domain III of the dengue-2 virus envelope protein., Huang KC, Lee MC, Wu CW, Huang KJ, Lei HY, Cheng JW, Proteins. 2008 Feb 15;70(3):1116-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18004779 18004779]
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cheng, J.]]
[[Category: Cheng J]]
[[Category: Huang, K.]]
[[Category: Huang K]]
[[Category: Domain iii]]
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:19:50 2008''
Retrieved from "https://proteopedia.org/2jsf"