2z0i: Difference between revisions
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< | ==Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus== | ||
<StructureSection load='2z0i' size='340' side='right'caption='[[2z0i]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2z0i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z0I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0i OCA], [https://pdbe.org/2z0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z0i RCSB], [https://www.ebi.ac.uk/pdbsum/2z0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0i ProSAT], [https://www.topsan.org/Proteins/RSGI/2z0i TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HEM2_MOUSE HEM2_MOUSE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0i_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z0i ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Porphobilinogen synthase|Porphobilinogen synthase]] | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Kawazoe M]] | |||
[[Category: Kishishita S]] | |||
[[Category: Kawazoe | [[Category: Murayama K]] | ||
[[Category: Kishishita | [[Category: Shirouzu M]] | ||
[[Category: Murayama | [[Category: Takemoto C]] | ||
[[Category: Terada T]] | |||
[[Category: Shirouzu | [[Category: Wang H]] | ||
[[Category: Takemoto | [[Category: Xie Y]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Wang | |||
[[Category: Xie | |||
[[Category: Yokoyama | |||
Latest revision as of 05:38, 17 October 2024
Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculus
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