3c2h: Difference between revisions

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==Crystal Structure of SYS-1 at 2.6A resolution==
The line below this paragraph, containing "STRUCTURE_3c2h", creates the "Structure Box" on the page.
<StructureSection load='3c2h' size='340' side='right'caption='[[3c2h]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3c2h|  PDB=3c2h  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2h OCA], [https://pdbe.org/3c2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2h RCSB], [https://www.ebi.ac.uk/pdbsum/3c2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2h ProSAT]</span></td></tr>
 
</table>
'''Crystal Structure of SYS-1 at 2.6A resolution'''
== Function ==
 
[https://www.uniprot.org/uniprot/Q9XVI2_CAEEL Q9XVI2_CAEEL]  
 
__TOC__
==Overview==
</StructureSection>
C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
 
==About this Structure==
3C2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2H OCA].  
 
==Reference==
The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18477457 18477457]
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Amaya, M F.]]
[[Category: Amaya MF]]
[[Category: Kimble, J.]]
[[Category: Kimble J]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: Phillips, B T.]]
[[Category: Phillips BT]]
[[Category: Xu, W.]]
[[Category: Xu W]]
[[Category: Beta-catenin]]
[[Category: Caenorhabditis elegan]]
[[Category: Cell adhesion]]
[[Category: Sys-1]]
[[Category: Wnt]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:54:11 2008''

Latest revision as of 09:32, 21 February 2024

Crystal Structure of SYS-1 at 2.6A resolution

3c2h, resolution 2.60Å

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