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New page: left|200px<br /><applet load="1bax" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bax" /> '''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NM...
 
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[[Image:1bax.gif|left|200px]]<br /><applet load="1bax" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bax" />
'''MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE'''<br />


==Overview==
==MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE==
The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D, retroviruses. In type B and D retroviruses, the Gag protein pre-assembles, before association with the membrane, whereas in type C retroviruses, (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma, membrane, where the particle formation occurs. The N-terminal domain of, Gag, the matrix protein (MA), plays a critical role in determining this, morphogenic difference. We have determined the three-dimensional solution, structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The, protein contains four alpha-helices that are structurally similar to the, known type C MA structures. This similarity implies possible common, assembly units and membrane-binding mechanisms for type C and B/D, retroviruses. In addition to this, the interpretation of mutagenesis data, has enabled us to identify, for the first time, the structural basis of a, putative intracellular targeting motif.
<StructureSection load='1bax' size='340' side='right'caption='[[1bax]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1bax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-Pfizer_monkey_virus Mason-Pfizer monkey virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1at7 1at7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAX FirstGlance]. <br>
1BAX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_mason-pfizer_virus Simian mason-pfizer virus]. This structure superseeds the now removed PDB entry 1AT7. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bax OCA], [https://pdbe.org/1bax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bax RCSB], [https://www.ebi.ac.uk/pdbsum/1bax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bax ProSAT]</span></td></tr>
==Reference==
</table>
The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly., Conte MR, Klikova M, Hunter E, Ruml T, Matthews S, EMBO J. 1997 Oct 1;16(19):5819-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9312040 9312040]
== Function ==
[[Category: Simian mason-pfizer virus]]
[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein.  P14 is the nucleocapsid protein.  p27 is the capsid protein.
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Conte, M.R.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Hunter, E.]]
Check<jmol>
[[Category: Klikova, M.]]
  <jmolCheckbox>
[[Category: Matthews, S.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bax_consurf.spt"</scriptWhenChecked>
[[Category: Ruml, T.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: core protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: matrix protein]]
  </jmolCheckbox>
[[Category: myristylation]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bax ConSurf].
[[Category: polyprotein]]
<div style="clear:both"></div>
 
__TOC__
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:30:53 2007''
</StructureSection>
[[Category: Large Structures]]
[[Category: Mason-Pfizer monkey virus]]
[[Category: Conte MR]]
[[Category: Hunter E]]
[[Category: Klikova M]]
[[Category: Matthews S]]
[[Category: Ruml T]]

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MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE

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