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New page: left|200px<br /><applet load="1bbi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bbi" /> '''THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPS...
 
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[[Image:1bbi.gif|left|200px]]<br /><applet load="1bbi" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bbi" />
'''THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION'''<br />


==Overview==
==THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION==
The three-dimensional structure of soybean trypsin/chymotrypsin, Bowman-Birk inhibitor in solution has been determined by two-dimensional, 1H nuclear magnetic resonance spectroscopy and dynamical simulated, annealing using the program XPLOR. The structure was defined by 907 NOEs, involving intra- and interresidue contacts which served as distance, constraints for a protocol of dynamical simulated annealing. In addition, 48 phi angle constraints involving non-proline amino acids, 29 chi angle, constraints, six omega angle constraints for the X-Pro peptide bond, and, 35 stereoassignments for prochiral centers were incorporated during the, course of the calculation. The protein is characterized by two distinct, binding domains for serine protease. Each domain is comprised of a, beta-hairpin (antiparallel beta-sheet and a cis-proline-containing type, VIb reverse turn) with a short segment making a third strand of, antiparallel beta-sheet. The structure determination and refinement are, described, and the structure is compared to other structures of, Bowman-Birk inhibitors as well as other families of serine protease, inhibitors.
<StructureSection load='1bbi' size='340' side='right'caption='[[1bbi]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BBI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bbi OCA], [https://pdbe.org/1bbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bbi RCSB], [https://www.ebi.ac.uk/pdbsum/1bbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bbi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IBB1_SOYBN IBB1_SOYBN] Inhibitor of trypsin and of chymotrypsin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/1bbi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bbi ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1BBI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BBI OCA].
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Three-dimensional structure of soybean trypsin/chymotrypsin Bowman-Birk inhibitor in solution., Werner MH, Wemmer DE, Biochemistry. 1992 Feb 4;31(4):999-1010. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1734975 1734975]
[[Category: Glycine max]]
[[Category: Glycine max]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Wemmer, D.E.]]
[[Category: Wemmer DE]]
[[Category: Werner, M.H.]]
[[Category: Werner MH]]
[[Category: serine protease inhibitor]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:31:29 2007''

Latest revision as of 15:31, 13 March 2024

THREE-DIMENSIONAL STRUCTURE OF SOYBEAN TRYPSIN(SLASH)CHYMOTRYPSIN BOWMAN-BIRK INHIBITOR IN SOLUTION

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