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New page: left|200px<br /><applet load="1bl0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bl0, resolution 2.300Å" /> '''MULTIPLE ANTIBIOTIC...
 
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[[Image:1bl0.gif|left|200px]]<br /><applet load="1bl0" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bl0, resolution 2.300&Aring;" />
'''MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX'''<br />


==Overview==
==MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX==
A crystal structure for a member of the AraC prokaryotic transcriptional, activator family, MarA, in complex with its cognate DNA-binding site is, described. MarA consists of two similar subdomains, each containing a, helix-turn-helix DNA-binding motif. The two recognition helices of the, motifs are inserted into adjacent major groove segments on the same face, of the DNA but are separated by only 27 A thereby bending the DNA by, approximately 35 degrees. Extensive interactions between the recognition, helices and the DNA major groove provide the sequence specificity.
<StructureSection load='1bl0' size='340' side='right'caption='[[1bl0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1bl0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BL0 FirstGlance]. <br>
1BL0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BL0 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bl0 OCA], [https://pdbe.org/1bl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bl0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bl0 ProSAT]</span></td></tr>
==Reference==
</table>
A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator., Rhee S, Martin RG, Rosner JL, Davies DR, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10413-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9724717 9724717]
== Function ==
[https://www.uniprot.org/uniprot/MARA_ECOLI MARA_ECOLI] May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1bl0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bl0 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Davies, S.]]
[[Category: Davies S]]
[[Category: Martin, J.L.]]
[[Category: Martin JL]]
[[Category: Rhee, R.G.]]
[[Category: Rhee RG]]
[[Category: Rosner, D.R.]]
[[Category: Rosner DR]]
[[Category: transcriptional activator; a bipartite helix-turn-helix protein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:44:06 2007''

Latest revision as of 06:37, 7 February 2024

MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN (MARA)/DNA COMPLEX

1bl0, resolution 2.30Å

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