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New page: left|200px<br /> <applet load="1hjz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hjz, resolution 1.7Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1hjz.gif|left|200px]]<br />
<applet load="1hjz" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1hjz, resolution 1.7&Aring;" />
'''CRYSTAL STRUCTURE OF AF1521 PROTEIN CONTAINING A MACROH2A DOMAIN'''<br />


==Overview==
==Crystal structure of AF1521 protein containing a macroH2A domain==
MacroH2A is an unusual histone H2A variant that has an extensive, C-terminal tail that comprises approximately two thirds of the protein., The C-terminal non-histone domain of macroH2A is also found in a number of, other proteins and has been termed the macro domain. Here we report the, crystal structure to 1.7A of AF1521, a protein consisting of a stand-alone, macro domain from Archaeoglobus fulgidus. The structure has a mixed, alpha/beta fold that closely resembles the N-terminal DNA binding domain, of the Escherichia coli leucine aminopeptidase PepA. The structure also, shows some similarity to members of the P-loop family of nucleotide, hydrolases.
<StructureSection load='1hjz' size='340' side='right'caption='[[1hjz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hjz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hjz OCA], [https://pdbe.org/1hjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hjz RCSB], [https://www.ebi.ac.uk/pdbsum/1hjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Y1521_ARCFU Y1521_ARCFU] Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Catalyzes removal of a phosphate group from ADP-ribose 1''-phosphate (Appr1p), but with low efficiency.<ref>PMID:23474712</ref> <ref>PMID:15902274</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hjz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjz ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
MacroH2A is an unusual histone H2A variant that has an extensive C-terminal tail that comprises approximately two thirds of the protein. The C-terminal non-histone domain of macroH2A is also found in a number of other proteins and has been termed the macro domain. Here we report the crystal structure to 1.7A of AF1521, a protein consisting of a stand-alone macro domain from Archaeoglobus fulgidus. The structure has a mixed alpha/beta fold that closely resembles the N-terminal DNA binding domain of the Escherichia coli leucine aminopeptidase PepA. The structure also shows some similarity to members of the P-loop family of nucleotide hydrolases.


==About this Structure==
The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A.,Allen MD, Buckle AM, Cordell SC, Lowe J, Bycroft M J Mol Biol. 2003 Jul 11;330(3):503-11. PMID:12842467<ref>PMID:12842467</ref>
1HJZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]] with MES as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HJZ OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A., Allen MD, Buckle AM, Cordell SC, Lowe J, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):503-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12842467 12842467]
</div>
<div class="pdbe-citations 1hjz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Allen, M.D.]]
[[Category: Allen MD]]
[[Category: Buckle, A.M.]]
[[Category: Buckle AM]]
[[Category: Bycroft, M.]]
[[Category: Bycroft M]]
[[Category: Cordell, S.C.]]
[[Category: Cordell SC]]
[[Category: Lowe, J.]]
[[Category: Lowe J]]
[[Category: MES]]
[[Category: crystal structure p-loop nucleotide hydrolase]]
[[Category: histone macroh2a]]
 
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