2jsq: Difference between revisions
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New page: '''Unreleased structure''' The entry 2jsq is ON HOLD Authors: Kuryavyi, V.V., Phan, A.T., Luu, K.N., Patel, D.J. Description: Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fol... |
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==Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures== | |||
<StructureSection load='2jsq' size='340' side='right'caption='[[2jsq]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2jsq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsq OCA], [https://pdbe.org/2jsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsq RCSB], [https://www.ebi.ac.uk/pdbsum/2jsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsq ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds. | |||
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.,Phan AT, Kuryavyi V, Luu KN, Patel DJ Nucleic Acids Res. 2007;35(19):6517-25. Epub 2007 Sep 25. PMID:17895279<ref>PMID:17895279</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2jsq" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Kuryavyi VV]] | |||
[[Category: Luu KN]] | |||
[[Category: Patel DJ]] | |||
[[Category: Phan AT]] | |||
Latest revision as of 12:48, 20 December 2023
Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures
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