2jx8: Difference between revisions

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New page: '''Unreleased structure''' The entry 2jx8 is ON HOLD until Paper Publication Authors: Kouno, T., Iwamoto, Y., Hirose, Y., Aizawa, T., Demura, M., Kawano, K., Ohkuma, Y., Mizuguchi, M. ...
 
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'''Unreleased structure'''


The entry 2jx8 is ON HOLD  until Paper Publication
==Solution structure of hPCIF1 WW domain==
 
<StructureSection load='2jx8' size='340' side='right'caption='[[2jx8]]' scene=''>
Authors: Kouno, T., Iwamoto, Y., Hirose, Y., Aizawa, T., Demura, M., Kawano, K., Ohkuma, Y., Mizuguchi, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2jx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX8 FirstGlance]. <br>
Description: Solution structure of hPCIF1 WW domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:32:44 2008''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx8 OCA], [https://pdbe.org/2jx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPAM_HUMAN CAPAM_HUMAN] Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).<ref>PMID:30467178</ref> <ref>PMID:30487554</ref> <ref>PMID:31279658</ref> <ref>PMID:31279659</ref> <ref>PMID:33428944</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jx8 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aizawa T]]
[[Category: Demura M]]
[[Category: Hirose Y]]
[[Category: Iwamoto Y]]
[[Category: Kawano K]]
[[Category: Kouno T]]
[[Category: Mizuguchi M]]
[[Category: Ohkuma Y]]
Retrieved from "https://proteopedia.org/2jx8"