2ra1: Difference between revisions

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New page: '''Unreleased structure''' The entry 2ra1 is ON HOLD until Paper Publication Authors: Pavkov, T., Egelseer, E.M., Tesarz, M., Sleytr, U.B., Keller, W. Description: Crystal structure of...
 
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'''Unreleased structure'''


The entry 2ra1 is ON HOLD  until Paper Publication
==Crystal structure of the N-terminal part of the bacterial S-layer protein SbsC==
<StructureSection load='2ra1' size='340' side='right'caption='[[2ra1]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ra1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RA1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.406&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ra1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra1 OCA], [https://pdbe.org/2ra1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ra1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ra1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ra1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O68840_GEOSE O68840_GEOSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ra/2ra1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ra1 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Surface layers (S-layers) comprise the outermost cell envelope component of most archaea and many bacteria. Here we present the structure of the bacterial S-layer protein SbsC from Geobacillus stearothermophilus, showing a very elongated and flexible molecule, with strong and specific binding to the secondary cell wall polymer (SCWP). The crystal structure of rSbsC((31-844)) revealed a novel fold, consisting of six separate domains, which are connected by short flexible linkers. The N-terminal domain exhibits positively charged residues regularly spaced along the putative ligand binding site matching the distance of the negative charges on the extended SCWP. Upon SCWP binding, a considerable stabilization of the N-terminal domain occurs. These findings provide insight into the processes of S-layer attachment to the underlying cell wall and self-assembly, and also accommodate the observed mechanical strength, the polarity of the S-layer, and the pronounced requirement for surface flexibility inherent to cell growth and division.


Authors: Pavkov, T., Egelseer, E.M., Tesarz, M., Sleytr, U.B., Keller, W.
The structure and binding behavior of the bacterial cell surface layer protein SbsC.,Pavkov T, Egelseer EM, Tesarz M, Svergun DI, Sleytr UB, Keller W Structure. 2008 Aug 6;16(8):1226-37. PMID:18682224<ref>PMID:18682224</ref>


Description: Crystal structure of the N-terminal part of the bacterial S-layer protein SbsC
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
<div class="pdbe-citations 2ra1" style="background-color:#fffaf0;"></div>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:48:15 2008''
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Large Structures]]
[[Category: Egelseer EM]]
[[Category: Keller W]]
[[Category: Pavkov T]]
[[Category: Sleytr UB]]
[[Category: Tesarz M]]
Retrieved from "https://proteopedia.org/2ra1"