2zhp: Difference between revisions
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New page: '''Unreleased structure''' The entry 2zhp is ON HOLD until Paper Publication Authors: Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Nonomura, Y., Osada, H. Descripti... |
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==Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative== | |||
<StructureSection load='2zhp' size='340' side='right'caption='[[2zhp]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2zhp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptoalloteichus_hindustanus Streptoalloteichus hindustanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BY6:[(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[(2,3-DIAMINO-3-OXOPROPYL)AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-AMINOPROPYLAMINO)BUTYLAMINO]PROPYLCARBAMOYL]-1,3-THIAZOL-2-YL]-1,3-THIAZOL-2-YL]ETHYLAMINO]-3-HYDROXY-1-OXOBUTAN-2-YL]AMINO]-3-HYDROXY-4-METHYL-5-OXOPENTAN-2-YL]AMINO]-1-(3H-IMIDAZOL-4-YL)-3-OXOPROPOXY]-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-4-YL]+CARBAMATE'>BY6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhp OCA], [https://pdbe.org/2zhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhp RCSB], [https://www.ebi.ac.uk/pdbsum/2zhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLE_STRHI BLE_STRHI] Binding protein with a strong affinity to the bleomycin family of antibiotics. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhp_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhp ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptoalloteichus hindustanus]] | |||
[[Category: Miyazaki I]] | |||
[[Category: Okumura H]] | |||
[[Category: Osada H]] | |||
[[Category: Simizu S]] | |||
Latest revision as of 13:57, 13 March 2024
Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative
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