3chn: Difference between revisions
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New page: '''Unreleased structure''' The entry 3chn is ON HOLD Authors: Bonner, A., Almogren, A., Furtado, P.B., Kerr, M.A., Perkins, S.J. Description: Solution structure of human secretory IgA1... |
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==Solution structure of human secretory IgA1== | |||
<StructureSection load='3chn' size='340' side='right'caption='[[3chn]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3chn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CHN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3chn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3chn OCA], [https://pdbe.org/3chn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3chn RCSB], [https://www.ebi.ac.uk/pdbsum/3chn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3chn ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3chn_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3chn ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Almogren A]] | |||
[[Category: Bonner A]] | |||
[[Category: Furtado PB]] | |||
[[Category: Kerr MA]] | |||
[[Category: Perkins SJ]] | |||
Latest revision as of 09:35, 21 February 2024
Solution structure of human secretory IgA1
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