3da6: Difference between revisions

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New page: '''Unreleased structure''' The entry 3da6 is ON HOLD Authors: Cee, V.J., Cheng, A.C., Romero, K., Bellon, S., Mohr, C., Whittington, D.A., Bready, J., Caenepeel, S., Coxon, A., Deak, H....
 
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'''Unreleased structure'''


The entry 3da6 is ON HOLD
==Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine==
<StructureSection load='3da6' size='340' side='right'caption='[[3da6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3da6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DA6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ9:N-[3-METHYL-4-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)NAPHTHALEN-1-YL]-1H-BENZIMIDAZOL-2-AMINE'>BZ9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3da6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3da6 OCA], [https://pdbe.org/3da6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3da6 RCSB], [https://www.ebi.ac.uk/pdbsum/3da6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3da6 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
== Function ==
[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3da6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3da6 ConSurf].
<div style="clear:both"></div>


Authors: Cee, V.J., Cheng, A.C., Romero, K., Bellon, S., Mohr, C., Whittington, D.A., Bready, J., Caenepeel, S., Coxon, A., Deak, H.L., Hodous, B.L., Kim, J.L., Lin, J., Nguyen, H., Olivieri, P.R., Patel, V.F., Wang, L., Hughes, P., Geuns-Meyer, S.
==See Also==
 
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
Description: Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine
== References ==
 
<references/>
 
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:38:37 2008''
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bellon S]]
[[Category: Bready J]]
[[Category: Caenepeel S]]
[[Category: Cee VJ]]
[[Category: Cheng AC]]
[[Category: Coxon A]]
[[Category: Deak HL]]
[[Category: Geuns-Meyer S]]
[[Category: Hodous BL]]
[[Category: Hughes P]]
[[Category: Kim JL]]
[[Category: Lin J]]
[[Category: Mohr C]]
[[Category: Nguyen H]]
[[Category: Olivieri PR]]
[[Category: Patel VF]]
[[Category: Romero K]]
[[Category: Wang L]]
[[Category: Whittington DA]]
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