2k20: Difference between revisions

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[[Image:2k20.jpg|left|200px]]


<!--
==Solution structure of Par-3 PDZ3 in complex with PTEN peptide==
The line below this paragraph, containing "STRUCTURE_2k20", creates the "Structure Box" on the page.
<StructureSection load='2k20' size='340' side='right'caption='[[2k20]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2k20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K20 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k20 OCA], [https://pdbe.org/2k20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k20 RCSB], [https://www.ebi.ac.uk/pdbsum/2k20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k20 ProSAT]</span></td></tr>
{{STRUCTURE_2k20|  PDB=2k20  |  SCENE= }}
</table>
 
== Function ==
'''Solution structure of Par-3 PDZ3 in complex with PTEN peptide'''
[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2K20 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K20 OCA].  
  <jmolCheckbox>
[[Category: Protein complex]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k20_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k20 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Chan, L.]]
[[Category: Chan L]]
[[Category: Feng, W.]]
[[Category: Feng W]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Zhang, M.]]
[[Category: Zhang M]]
[[Category: Alternative splicing]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell junction]]
[[Category: Cell polarity]]
[[Category: Coiled coil]]
[[Category: Membrane]]
[[Category: Par-3]]
[[Category: Pdz domain]]
[[Category: Phosphoprotein]]
[[Category: Pten]]
[[Category: Scaffold protein]]
[[Category: Signaling protein]]
[[Category: Tight junction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:43:23 2008''
Retrieved from "https://proteopedia.org/2k20"