2v7n: Difference between revisions

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[[Image:2v7n.jpg|left|200px]]


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==Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4==
The line below this paragraph, containing "STRUCTURE_2v7n", creates the "Structure Box" on the page.
<StructureSection load='2v7n' size='340' side='right'caption='[[2v7n]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2v7n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7N FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7n OCA], [https://pdbe.org/2v7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7n RCSB], [https://www.ebi.ac.uk/pdbsum/2v7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7n ProSAT]</span></td></tr>
{{STRUCTURE_2v7n|  PDB=2v7n  |  SCENE=  }}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v7n ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models revealed deviations in a few framework positions and in the binding loops. The crystals belong to space group P2(1)2(1)2 and contain four molecules in the asymmetric unit, with unit-cell parameters a=102.77, b=185.92, c=102.97 A. These particular unit-cell parameters allowed pseudo-merohedral twinning; interestingly, the twinning law relates a twofold screw axis to a twofold axis.


'''UNUSUAL TWINNING IN CRYSTALS OF THE CITS BINDING ANTIBODY FAB FRAGMENT F3P4'''
Structure of the recombinant antibody Fab fragment f3p4.,Frey D, Huber T, Pluckthun A, Grutter MG Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151<ref>PMID:18560151</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2V7N is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA].
<div class="pdbe-citations 2v7n" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Frey, D.]]
<references/>
[[Category: Gruetter, M G.]]
__TOC__
[[Category: Huber, T.]]
</StructureSection>
[[Category: Plueckthun, A.]]
[[Category: Large Structures]]
[[Category: Binding protein]]
[[Category: Synthetic construct]]
[[Category: Immune system]]
[[Category: Frey D]]
[[Category: Phage display]]
[[Category: Gruetter MG]]
[[Category: Recombinant fab fragment]]
[[Category: Huber T]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:04:24 2008''
[[Category: Plueckthun A]]
Retrieved from "https://proteopedia.org/2v7n"