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New page: left|200px<br /> <applet load="2j3p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j3p, resolution 1.40Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:2j3p.gif|left|200px]]<br />
<applet load="2j3p" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2j3p, resolution 1.40&Aring;" />
'''CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A'''<br />


==Overview==
==crystal structure of rat FGF1 at 1.4 A==
Fibroblast growth factors (FGFs) constitute a family of 22 structurally, related heparin-binding polypeptides that are involved in the regulation, of cell growth, survival, differentiation and migration. Here, a 1.4 A, resolution X-ray structure of rat FGF1 is presented. Two molecules are, present in the asymmetric unit of the crystal and they coordinate a total, of five sulfate ions. The structures of human, bovine and newt FGF1 have, been published previously. Human and rat FGF1 are found to have very, similar structures.
<StructureSection load='2j3p' size='340' side='right'caption='[[2j3p]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2j3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J3P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j3p OCA], [https://pdbe.org/2j3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j3p RCSB], [https://www.ebi.ac.uk/pdbsum/2j3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j3p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FGF1_RAT FGF1_RAT] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j3p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j3p ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.


==About this Structure==
Structure of rat acidic fibroblast growth factor at 1.4 A resolution.,Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:17277441<ref>PMID:17277441</ref>
2J3P is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of rat acidic fibroblast growth factor at 1.4 A resolution., Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17277441 17277441]
</div>
<div class="pdbe-citations 2j3p" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Berezin V]]
[[Category: Berezin, V.]]
[[Category: Bock E]]
[[Category: Bock, E.]]
[[Category: Gajhede M]]
[[Category: Gajhede, M.]]
[[Category: Kristensen O]]
[[Category: Kristensen, O.]]
[[Category: Kulahin N]]
[[Category: Kulahin, N.]]
[[Category: SO4]]
[[Category: acidic fibroblast growth factor]]
[[Category: angiogenesis]]
[[Category: beta-trefoil]]
[[Category: cytokine]]
[[Category: developmental protein]]
[[Category: differentiation]]
[[Category: growth factor]]
[[Category: heparin-binding]]
[[Category: mitogen]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:32:32 2007''

Latest revision as of 14:33, 13 December 2023

crystal structure of rat FGF1 at 1.4 A

2j3p, resolution 1.40Å

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