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New page: left|200px<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1csn, resolution 2.0Å" /> '''BINARY COMPLEX OF CAS...
 
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[[Image:1csn.gif|left|200px]]<br /><applet load="1csn" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1csn, resolution 2.0&Aring;" />
'''BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP'''<br />


==Overview==
==BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP==
The structure of a truncated variant of casein kinase-1 from, Schizosaccharomyces pombe, has been determined in complex with MgATP at, 2.0 A resolution. The model resembles the 'closed', ATP-bound, conformations of the cyclin-dependent kinase 2 and the cAMP-dependent, protein kinase, with clear differences in the structure of surface loops, that impart unique features to casein kinase-1. The structure is of, unphosphorylated, active conformation of casein kinase-1 and the, peptide-binding site is fully accessible to substrate.
<StructureSection load='1csn' size='340' side='right'caption='[[1csn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1csn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CSN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1csn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csn OCA], [https://pdbe.org/1csn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1csn RCSB], [https://www.ebi.ac.uk/pdbsum/1csn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1csn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CKI1_SCHPO CKI1_SCHPO] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/1csn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1csn ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1CSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] with MG, SO4 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CSN OCA].
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of casein kinase-1, a phosphate-directed protein kinase., Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X, EMBO J. 1995 Mar 1;14(5):1015-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7889932 7889932]
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Single protein]]
[[Category: Cheng X]]
[[Category: Cheng, X.]]
[[Category: Xu R-M]]
[[Category: Xu, R.M.]]
[[Category: ATP]]
[[Category: MG]]
[[Category: SO4]]
[[Category: phosphotransferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:43:38 2007''

Latest revision as of 06:45, 7 February 2024

BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP

1csn, resolution 2.00Å

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