1d2d: Difference between revisions
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New page: left|200px<br /><applet load="1d2d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2d" /> '''HAMSTER EPRS SECOND REPEATED ELEMENT; NMR, 1... |
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== | ==Hamster EprS second repeated element. NMR, 5 structures== | ||
Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide | <StructureSection load='1d2d' size='340' side='right'caption='[[1d2d]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1d2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2d OCA], [https://pdbe.org/1d2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2d RCSB], [https://www.ebi.ac.uk/pdbsum/1d2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SYEP_CRIGR SYEP_CRIGR] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2d_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2d ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor. | |||
A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.,Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942<ref>PMID:10654942</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1d2d" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Berthonneau | [[Category: Berthonneau E]] | ||
[[Category: Birlirakis | [[Category: Birlirakis N]] | ||
[[Category: Cahuzac | [[Category: Cahuzac B]] | ||
[[Category: Guittet | [[Category: Guittet E]] | ||
[[Category: Mirande | [[Category: Mirande M]] | ||
Latest revision as of 08:22, 22 May 2024
Hamster EprS second repeated element. NMR, 5 structures
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