1d2z: Difference between revisions

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New page: left|200px<br /><applet load="1d2z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2z, resolution 2.0Å" /> '''THREE-DIMENSIONAL STR...
 
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[[Image:1d2z.gif|left|200px]]<br /><applet load="1d2z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1d2z, resolution 2.0&Aring;" />
'''THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE'''<br />


==Overview==
==THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE==
The interaction of the serine/threonine kinase Pelle and adaptor protein, Tube through their N-terminal death domains leads to the nuclear, translocation of the transcription factor Dorsal and activation of zygotic, patterning genes during Drosophila embryogenesis. Crystal structure of the, Pelle and Tube death domain heterodimer reveals that the two death domains, adopt a six-helix bundle fold and are arranged in an open-ended linear, array with plastic interfaces mediating their interactions. The Tube death, domain has an insertion between helices 2 and 3, and a C-terminal tail, making significant and indispensable contacts in the heterodimer. In vivo, assays of Pelle and Tube mutants confirmed that the integrity of the major, heterodimer interface is critical to the activity of these molecules.
<StructureSection load='1d2z' size='340' side='right'caption='[[1d2z]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1d2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2Z FirstGlance]. <br>
1D2Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with EPE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D2Z OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2z OCA], [https://pdbe.org/1d2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2z RCSB], [https://www.ebi.ac.uk/pdbsum/1d2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2z ProSAT]</span></td></tr>
Three-dimensional structure of a complex between the death domains of Pelle and Tube., Xiao T, Towb P, Wasserman SA, Sprang SR, Cell. 1999 Nov 24;99(5):545-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10589682 10589682]
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPEL_DROME KPEL_DROME] Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.<ref>PMID:8440018</ref> <ref>PMID:7527496</ref> <ref>PMID:7635064</ref> <ref>PMID:10330490</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2z ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Sprang, S.R.]]
[[Category: Sprang SR]]
[[Category: Towb, P.]]
[[Category: Towb P]]
[[Category: Wasserman, S.A.]]
[[Category: Wasserman SA]]
[[Category: Xiao, T.]]
[[Category: Xiao T]]
[[Category: EPE]]
[[Category: apoptosis]]
[[Category: linear array of death domains]]
[[Category: plastic interfaces]]
[[Category: six-helix bundle]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:58:51 2007''
Retrieved from "https://proteopedia.org/1d2z"