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[[Image:1ihb.png|left|200px]]


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==CRYSTAL STRUCTURE OF P18-INK4C(INK6)==
The line below this paragraph, containing "STRUCTURE_1ihb", creates the "Structure Box" on the page.
<StructureSection load='1ihb' size='340' side='right'caption='[[1ihb]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ihb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IHB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihb OCA], [https://pdbe.org/1ihb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ihb RCSB], [https://www.ebi.ac.uk/pdbsum/1ihb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ihb ProSAT]</span></td></tr>
{{STRUCTURE_1ihb|  PDB=1ihb  |  SCENE= }}
</table>
 
== Function ==
'''CRYSTAL STRUCTURE OF P18-INK4C(INK6)'''
[https://www.uniprot.org/uniprot/CDN2C_HUMAN CDN2C_HUMAN] Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
p18INK4c is a member of a family of INK4 proteins that function to arrest the G1 to S cell cycle transition by inhibiting the activity of the cyclin-dependent kinases 4 and 6. The X-ray crystal structure of the human p18INK4c protein to a resolution of 1.95 A reveals an elongated molecule comprised of five contiguous 32- or 33-residue ankyrin-like repeat units. Each ankyrin-like repeat contains a beta-strand helix-turn-helix extended strand beta-strand motif that associates with neighboring motifs through beta-sheet, and helical bundle interactions. Conserved ankyrin-like repeat residues function to facilitate the ankyrin repeat fold and the tertiary interactions between neighboring repeat units. A large percentage of residues that are conserved among INK4 proteins and that map to positions of tumor-derived p16INK4 mutations play important roles in protein stability. A subset of these residues suggest an INK4 binding surface for the cyclin-dependent kinases 4 and 6. This surface is centered around a region that shows structural features uncharacteristic of ankyrin-like repeat units.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/1ihb_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1IHB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHB OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ihb ConSurf].
Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations., Venkataramani R, Swaminathan K, Marmorstein R, Nat Struct Biol. 1998 Jan;5(1):74-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9437433 9437433]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Marmorstein, R.]]
[[Category: Marmorstein R]]
[[Category: Ravichandran, V.]]
[[Category: Ravichandran V]]
[[Category: Swaminathan, K.]]
[[Category: Swaminathan K]]
[[Category: Ankyrin repeat]]
[[Category: Cdk 4/6 inhibitor]]
[[Category: Cell cycle inhibitor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jun 24 23:22:06 2008''
Retrieved from "https://proteopedia.org/1ihb"