2v31: Difference between revisions
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==Structure of First Catalytic Cysteine Half-domain of mouse ubiquitin- activating enzyme== | |||
<StructureSection load='2v31' size='340' side='right'caption='[[2v31]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2v31]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V31 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V31 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z7l|1z7l]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v31 OCA], [http://pdbe.org/2v31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v31 RCSB], [http://www.ebi.ac.uk/pdbsum/2v31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v31 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/UBA1_MOUSE UBA1_MOUSE]] Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/2v31_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v31 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Ubiquitin activating enzyme|Ubiquitin activating enzyme]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
== | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Bochtler, M]] | |||
[[Category: Bochtler, M | [[Category: Filipek, R]] | ||
[[Category: Filipek, R | [[Category: Jaremko, L]] | ||
[[Category: Jaremko, L | [[Category: Jaremko, M]] | ||
[[Category: Jaremko, M | [[Category: Szczepanowski, R H]] | ||
[[Category: Szczepanowski, R H | [[Category: Wojciechowski, W]] | ||
[[Category: Wojciechowski, W | [[Category: Zhukov, I]] | ||
[[Category: Zhukov, I | |||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
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[[Category: Ubiquitination]] | [[Category: Ubiquitination]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||