1hyk: Difference between revisions

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[[Image:1hyk.png|left|200px]]


<!--
==AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132))==
The line below this paragraph, containing "STRUCTURE_1hyk", creates the "Structure Box" on the page.
<StructureSection load='1hyk' size='340' side='right'caption='[[1hyk]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qu8 1qu8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HYK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyk OCA], [https://pdbe.org/1hyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hyk RCSB], [https://www.ebi.ac.uk/pdbsum/1hyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hyk ProSAT]</span></td></tr>
{{STRUCTURE_1hyk|  PDB=1hyk  |  SCENE= }}
</table>
 
== Disease ==
'''AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132))'''
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref>
 
== Function ==
 
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref>
{{ABSTRACT_10371151}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
1HYK is a [[Single protein]] structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qu8 1qu8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYK OCA].  
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hyk_consurf.spt"</scriptWhenChecked>
[[Category: Anderson, D J.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Bolin, K A.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Kent, S B.H.]]
  </jmolCheckbox>
[[Category: Millhauser, G L.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hyk ConSurf].
[[Category: Thompson, D A.]]
<div style="clear:both"></div>
[[Category: Trulson, J A.]]
== References ==
[[Category: Wilken, J.]]
<references/>
[[Category: Agouti]]
__TOC__
[[Category: Agouti-related]]
</StructureSection>
[[Category: Agrp]]
[[Category: Homo sapiens]]
[[Category: Cysteine rich]]
[[Category: Large Structures]]
[[Category: Disulfide bond]]
[[Category: Anderson DJ]]
[[Category: Endogenous antagonist]]
[[Category: Bolin KA]]
[[Category: Ick]]
[[Category: Kent SBH]]
[[Category: Inhibitor cystine knot]]
[[Category: Millhauser GL]]
[[Category: Melanocortin antagonist]]
[[Category: Thompson DA]]
 
[[Category: Trulson JA]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 19:21:27 2008''
[[Category: Wilken J]]
Retrieved from "https://proteopedia.org/1hyk"