1l2y: Difference between revisions

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~~[[Image:1l2y.png|left|200px]]~~

<!--

==NMR Structure of Trp-Cage Miniprotein Construct TC5b==

~~The line below this paragraph, containing~~ "~~STRUCTURE_1l2y~~", ~~creates the~~ "~~Structure Box~~" ~~on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

== Structural highlights ==

or the ~~SCENE parameter (which sets~~ the ~~initial scene displayed when~~ the ~~page is loaded)~~,

<table><tr><td colspan='2'>[[1l2y]] is a 1 chain structure. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Y FirstGlance]. <br>

~~or leave the SCENE parameter empty~~ for the ~~default display~~.

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

~~-->~~

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2y OCA], [https://pdbe.org/1l2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2y RCSB], [https://www.ebi.ac.uk/pdbsum/1l2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2y ProSAT]</span></td></tr>

~~{{STRUCTURE_1l2y| PDB=1l2y | SCENE= }}~~

</table>

== Publication Abstract from PubMed ==

Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue constructs that are >95% folded in water at physiological pH. These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative and hydrophobically driven by the encapsulation of a Trp side chain in a sheath of Pro rings. As the smallest protein-like construct, Trp-cage miniproteins should provide a testing ground for both experimental studies and computational simulations of protein folding and unfolding pathways. Pro Trp interactions may be a particularly effective strategy for the a priori design of self-folding peptides.

~~'''NMR Structure of Trp~~-~~Cage Miniprotein Construct TC5b'''~~

Designing a 20-residue protein.,Neidigh JW, Fesinmeyer RM, Andersen NH Nat Struct Biol. 2002 Jun;9(6):425-30. PMID:11979279<ref>PMID:11979279</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~{{ABSTRACT_11979279}}~~

</div>

==~~About this Structure~~==

== References ==

~~The following page contains interesting information on the relation of 1L2Y with [[http:~~//pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA].

__TOC__

</StructureSection>

[[Category: Designer Proteins]]

[[Category: ~~Andersen, N H.~~]]

[[Category: Large Structures]]

[[Category: ~~Fesinmeyer, R M.~~]]

[[Category: RCSB PDB Molecule of the Month]]

[[Category: ~~Neidigh, J W.~~]]

[[Category: Andersen NH]]

[[Category: ~~Miniprotein~~]]

[[Category: Fesinmeyer RM]]

[[Category: ~~Trp-cage]]~~

[[Category: Neidigh JW]]

~~[[Category: Two-state folding~~]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:40:01 2008''~~

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@@ Line 1: / Line 1: @@
-[[Image:1l2y.png|left|200px]]
-<!--
+==NMR Structure of Trp-Cage Miniprotein Construct TC5b==
-The line below this paragraph, containing "STRUCTURE_1l2y", creates the "Structure Box" on the page.
+<StructureSection load='1l2y' size='340' side='right'caption='[[1l2y]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1l2y]] is a 1 chain structure. The October 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designer Proteins''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_10 10.2210/rcsb_pdb/mom_2005_10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Y FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2y OCA], [https://pdbe.org/1l2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2y RCSB], [https://www.ebi.ac.uk/pdbsum/1l2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2y ProSAT]</span></td></tr>
-{{STRUCTURE_1l2y|  PDB=1l2y  |  SCENE=  }}
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue constructs that are &gt;95% folded in water at physiological pH. These constructs optimize a novel fold, designated as the 'Trp-cage' motif, and are significantly more stable than any other miniprotein reported to date. Folding is cooperative and hydrophobically driven by the encapsulation of a Trp side chain in a sheath of Pro rings. As the smallest protein-like construct, Trp-cage miniproteins should provide a testing ground for both experimental studies and computational simulations of protein folding and unfolding pathways. Pro Trp interactions may be a particularly effective strategy for the a priori design of self-folding peptides.
-'''NMR Structure of Trp-Cage Miniprotein Construct TC5b'''
+Designing a 20-residue protein.,Neidigh JW, Fesinmeyer RM, Andersen NH Nat Struct Biol. 2002 Jun;9(6):425-30. PMID:11979279<ref>PMID:11979279</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-{{ABSTRACT_11979279}}
+</div>
+<div class="pdbe-citations 1l2y" style="background-color:#fffaf0;"></div>
-==About this Structure==
+== References ==
-The following page contains interesting information on the relation of 1L2Y with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Y OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Designer Proteins]]
-[[Category: Andersen, N H.]]
+[[Category: Large Structures]]
-[[Category: Fesinmeyer, R M.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Neidigh, J W.]]
+[[Category: Andersen NH]]
-[[Category: Miniprotein]]
+[[Category: Fesinmeyer RM]]
-[[Category: Trp-cage]]
+[[Category: Neidigh JW]]
-[[Category: Two-state folding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:40:01 2008''