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New page: left|200px<br /><applet load="1dir" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dir, resolution 2.60Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1dir.gif|left|200px]]<br /><applet load="1dir" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1dir, resolution 2.60&Aring;" />
'''CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER'''<br />


==Overview==
==CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER==
A binary complex of dihydropteridine reductase and NADH crystallizes in, the space group C2, with a = 222.2, b = 46.5, c = 95.3 A and beta = 101.1, degrees. There are two dimers in the asymmetric unit. The structure was, solved by molecular-replacement techniques and refined with 2.6 A data to, a crystallographic R factor of 16.8%. Each dimer has twofold, non-crystallographic symmetry and the four individual monomers in the, asymmetric unit have the same overall molecular conformation.
<StructureSection load='1dir' size='340' side='right'caption='[[1dir]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1dir]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DIR FirstGlance]. <br>
1DIR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with NAD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DIR OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dir OCA], [https://pdbe.org/1dir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dir RCSB], [https://www.ebi.ac.uk/pdbsum/1dir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dir ProSAT]</span></td></tr>
Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver., Su Y, Skinner MM, Xuong NH, Matthews DA, Whiteley JM, Varughese KI, Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):884-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299357 15299357]
</table>
[[Category: 6,7-dihydropteridine reductase]]
== Function ==
[https://www.uniprot.org/uniprot/DHPR_RAT DHPR_RAT] The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1dir_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dir ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Matthews DA]]
[[Category: Matthews, D.A.]]
[[Category: Skinner MM]]
[[Category: Skinner, M.M.]]
[[Category: Su Y]]
[[Category: Su, Y.]]
[[Category: Varughese KI]]
[[Category: Varughese, K.I.]]
[[Category: Whitely JM]]
[[Category: Whitely, J.M.]]
[[Category: Xuong NH]]
[[Category: Xuong, N.H.]]
[[Category: NAD]]
[[Category: oxidoreductase(acting on nadh or nadph)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:18:34 2007''
Retrieved from "https://proteopedia.org/1dir"