1a1x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1a1x.png|left|200px]]


<!--
==CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES==
The line below this paragraph, containing "STRUCTURE_1a1x", creates the "Structure Box" on the page.
<StructureSection load='1a1x' size='340' side='right'caption='[[1a1x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1x OCA], [https://pdbe.org/1a1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1x RCSB], [https://www.ebi.ac.uk/pdbsum/1a1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1x ProSAT]</span></td></tr>
{{STRUCTURE_1a1x|  PDB=1a1x  |  SCENE=  }}
</table>
 
== Disease ==
===CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES===
[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
 
== Function ==
 
[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
<!--
== Evolutionary Conservation ==
The line below this paragraph, {{ABSTRACT_PUBMED_9520380}}, adds the Publication Abstract to the page
[[Image:Consurf_key_small.gif|200px|right]]
(as it appears on PubMed at http://www.pubmed.gov), where 9520380 is the PubMed ID number.
Check<jmol>
-->
  <jmolCheckbox>
{{ABSTRACT_PUBMED_9520380}}
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1x_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
1A1X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1x ConSurf].
==Reference==
<div style="clear:both"></div>
Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies., Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW, Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3413-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9520380 9520380]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Croce, C M.]]
[[Category: Croce CM]]
[[Category: Dubois, G C.]]
[[Category: Dubois GC]]
[[Category: Fu, Z Q.]]
[[Category: Fu ZQ]]
[[Category: Harrison, R W.]]
[[Category: Harrison RW]]
[[Category: Kulikovskaya, I.]]
[[Category: Kulikovskaya I]]
[[Category: Rothstein, J.]]
[[Category: Rothstein J]]
[[Category: Song, S P.]]
[[Category: Song SP]]
[[Category: Virgilio, L.]]
[[Category: Virgilio L]]
[[Category: Weber, I T.]]
[[Category: Weber IT]]
[[Category: Crystal structure]]
[[Category: Mtcp-1]]
[[Category: Oncogene involved in t cell malignancy]]
[[Category: Proto-oncogene]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:09 2008''
Retrieved from "https://proteopedia.org/1a1x"