1aqf: Difference between revisions

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{{Seed}}
[[Image:1aqf.png|left|200px]]


<!--
==PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE==
The line below this paragraph, containing "STRUCTURE_1aqf", creates the "Structure Box" on the page.
<StructureSection load='1aqf' size='340' side='right'caption='[[1aqf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1aqf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEQ:L-PHOSPHOLACTATE'>PEQ</scene></td></tr>
{{STRUCTURE_1aqf| PDB=1aqf |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqf OCA], [https://pdbe.org/1aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqf RCSB], [https://www.ebi.ac.uk/pdbsum/1aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPYM_RABIT KPYM_RABIT] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqf ConSurf].
<div style="clear:both"></div>


===PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE===
==See Also==
 
*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9308890}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9308890 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9308890}}
 
==About this Structure==
1AQF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQF OCA].
 
==Reference==
Ligand-induced domain movement in pyruvate kinase: structure of the enzyme from rabbit muscle with Mg2+, K+, and L-phospholactate at 2.7 A resolution., Larsen TM, Benning MM, Wesenberg GE, Rayment I, Reed GH, Arch Biochem Biophys. 1997 Sep 15;345(2):199-206. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9308890 9308890]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Pyruvate kinase]]
[[Category: Benning MM]]
[[Category: Single protein]]
[[Category: Larsen TM]]
[[Category: Benning, M M.]]
[[Category: Rayment I]]
[[Category: Larsen, T M.]]
[[Category: Reed GH]]
[[Category: Rayment, I.]]
[[Category: Wesenberg GE]]
[[Category: Reed, G H.]]
[[Category: Wesenberg, G E.]]
[[Category: Domain movement]]
[[Category: Potassium binding]]
[[Category: Pyruvate kinase]]
[[Category: Rabbit muscle]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:24:34 2008''

Latest revision as of 06:32, 7 February 2024

PYRUVATE KINASE FROM RABBIT MUSCLE WITH MG, K, AND L-PHOSPHOLACTATE

1aqf, resolution 2.70Å

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