1b4e: Difference between revisions

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{{Seed}}
[[Image:1b4e.png|left|200px]]


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==X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid==
The line below this paragraph, containing "STRUCTURE_1b4e", creates the "Structure Box" on the page.
<StructureSection load='1b4e' size='340' side='right'caption='[[1b4e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1b4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SHF:LAEVULINIC+ACID'>SHF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1b4e| PDB=1b4e |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4e OCA], [https://pdbe.org/1b4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4e RCSB], [https://www.ebi.ac.uk/pdbsum/1b4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HEM2_ECOLI HEM2_ECOLI] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/1b4e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b4e ConSurf].
<div style="clear:both"></div>


===X-RAY STRUCTURE OF 5-AMINOLEVULINIC ACID DEHYDRATASE COMPLEXED WITH THE INHIBITOR LEVULINIC ACID.===
==See Also==
 
*[[Porphobilinogen synthase|Porphobilinogen synthase]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10194344}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10194344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10194344}}
 
==About this Structure==
1B4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4E OCA].
 
==Reference==
X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution., Erskine PT, Norton E, Cooper JB, Lambert R, Coker A, Lewis G, Spencer P, Sarwar M, Wood SP, Warren MJ, Shoolingin-Jordan PM, Biochemistry. 1999 Apr 6;38(14):4266-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10194344 10194344]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Porphobilinogen synthase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Cooper JB]]
[[Category: Cooper, J B.]]
[[Category: Erskine PT]]
[[Category: Erskine, P T.]]
[[Category: Lewis G]]
[[Category: Lewis, G.]]
[[Category: Shoolingin-Jordan PM]]
[[Category: Shoolingin-Jordan, P M.]]
[[Category: Spencer P]]
[[Category: Spencer, P.]]
[[Category: Wood SP]]
[[Category: Wood, S P.]]
[[Category: Dehydratase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:13:47 2008''

Latest revision as of 05:55, 3 April 2024

X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid

1b4e, resolution 2.00Å

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