1b8x: Difference between revisions

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{{Seed}}
[[Image:1b8x.png|left|200px]]


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==GLUTATHIONE S-TRANSFERASE FUSED WITH THE NUCLEAR MATRIX TARGETING SIGNAL OF THE TRANSCRIPTION FACTOR AML-1==
The line below this paragraph, containing "STRUCTURE_1b8x", creates the "Structure Box" on the page.
<StructureSection load='1b8x' size='340' side='right'caption='[[1b8x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1b8x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8x OCA], [https://pdbe.org/1b8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8x RCSB], [https://www.ebi.ac.uk/pdbsum/1b8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8x ProSAT]</span></td></tr>
{{STRUCTURE_1b8x|  PDB=1b8x  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b8x ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A glutathione S-transferase fused with the nuclear matrix targeting signal (GST-NMTS) of AML-1/CBF-alpha2 has been crystallized by the vapor diffusion method using polyethylene glycol (PEG) as the precipitant. The NMTS is a 31-amino-acid signal peptide that can target the AML-1/CBF-alpha2 protein to the nuclear matrix. The crystal belongs to tetragonal space group P43212 with unit cell dimensions a = b = 93.4 A, c = 57.6 A. There is one GST-fusion protein per asymmetric unit. Crystals diffracted to at least 2.7 A and are appropriate for structure determination.


===GLUTATHIONE S-TRANSFERASE FUSED WITH THE NUCLEAR MATRIX TARGETING SIGNAL OF THE TRANSCRIPTION FACTOR AML-1===
Preliminary crystallographic study of glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBF-alpha2.,Tang L, Guo B, van Wijnen AJ, Lian JB, Stein JL, Stein GS, Zhou GW J Struct Biol. 1998 Sep;123(1):83-5. PMID:9774548<ref>PMID:9774548</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_9774548}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1b8x" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9774548 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_9774548}}
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</StructureSection>
==About this Structure==
1B8X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8X OCA].
 
==Reference==
Preliminary crystallographic study of glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBF-alpha2., Tang L, Guo B, van Wijnen AJ, Lian JB, Stein JL, Stein GS, Zhou GW, J Struct Biol. 1998 Sep;123(1):83-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9774548 9774548]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Guo, B.]]
[[Category: Guo B]]
[[Category: Lian, J B.]]
[[Category: Lian JB]]
[[Category: Stein, G S.]]
[[Category: Stein GS]]
[[Category: Stein, J L.]]
[[Category: Stein JL]]
[[Category: Tang, L.]]
[[Category: Tang L]]
[[Category: Wijnen, A J.Van.]]
[[Category: Van Wijnen AJ]]
[[Category: Zhou, G W.]]
[[Category: Zhou GW]]
[[Category: Nuclear matrix targeting signal protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:35:39 2008''

Latest revision as of 05:38, 9 August 2023

GLUTATHIONE S-TRANSFERASE FUSED WITH THE NUCLEAR MATRIX TARGETING SIGNAL OF THE TRANSCRIPTION FACTOR AML-1

1b8x, resolution 2.70Å

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