1bau: Difference between revisions

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{{Seed}}
[[Image:1bau.png|left|200px]]


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==NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE==
The line below this paragraph, containing "STRUCTURE_1bau", creates the "Structure Box" on the page.
<StructureSection load='1bau' size='340' side='right'caption='[[1bau]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1bau]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bau OCA], [https://pdbe.org/1bau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bau RCSB], [https://www.ebi.ac.uk/pdbsum/1bau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bau ProSAT]</span></td></tr>
{{STRUCTURE_1bau|  PDB=1bau  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.


===NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE===
Structure of the dimer initiation complex of HIV-1 genomic RNA.,Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479<ref>PMID:9628479</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1bau" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9628479 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_9628479}}
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</StructureSection>
==About this Structure==
[[Category: Human immunodeficiency virus 1]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
[[Category: Large Structures]]
 
[[Category: Billeci TM]]
==Reference==
[[Category: Clever JL]]
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9628479 9628479]
[[Category: James TL]]
[[Category: Billeci, T M.]]
[[Category: Mujeeb A]]
[[Category: Clever, J L.]]
[[Category: Parslow TG]]
[[Category: James, T L.]]
[[Category: Mujeeb, A.]]
[[Category: Parslow, T G.]]
[[Category: Dimerization]]
[[Category: Encapsidation]]
[[Category: Hiv-1]]
[[Category: Ribonucleic acid]]
[[Category: Rna]]
 
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