1big: Difference between revisions

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{{Seed}}
[[Image:1big.png|left|200px]]


<!--
==SCORPION TOXIN BMTX1 FROM BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1big", creates the "Structure Box" on the page.
<StructureSection load='1big' size='340' side='right'caption='[[1big]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1big]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BIG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
{{STRUCTURE_1big| PDB=1big |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1big FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1big OCA], [https://pdbe.org/1big PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1big RCSB], [https://www.ebi.ac.uk/pdbsum/1big PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1big ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAX15_MESMA KAX15_MESMA] Potent blocker of both large-conductance calcium-activated potassium channels (BKCa channels) and voltage-gated potassium channels (Kv1.3/KCNA3).<ref>PMID:9354615</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/1big_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1big ConSurf].
<div style="clear:both"></div>


===SCORPION TOXIN BMTX1 FROM BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES===
==See Also==
 
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_9730813}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 9730813 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_9730813}}
 
==About this Structure==
1BIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIG OCA].
 
==Reference==
Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels., Blanc E, Romi-Lebrun R, Bornet O, Nakajima T, Darbon H, Biochemistry. 1998 Sep 8;37(36):12412-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9730813 9730813]
[[Category: Mesobuthus martensii]]
[[Category: Mesobuthus martensii]]
[[Category: Single protein]]
[[Category: Blanc E]]
[[Category: Blanc, E.]]
[[Category: Bornet O]]
[[Category: Bornet, O.]]
[[Category: Darbon H]]
[[Category: Darbon, H.]]
[[Category: Nakajima T]]
[[Category: Nakajima, T.]]
[[Category: Romi-Lebrun R]]
[[Category: Romi-Lebrun, R.]]
[[Category: Buthus martensii]]
[[Category: Large conductance potassium channel]]
[[Category: Neurotoxin]]
[[Category: Nmr]]
[[Category: Scorpion]]
[[Category: Structure]]
[[Category: Toxin]]
[[Category: Voltage gated potassium channel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:12:57 2008''

Latest revision as of 15:33, 13 March 2024

SCORPION TOXIN BMTX1 FROM BUTHUS MARTENSII KARSCH, NMR, 25 STRUCTURES

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