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New page: left|200px<br /><applet load="1ei3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ei3, resolution 5.5Å" /> '''CRYSTAL STRUCTURE OF ...
 
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[[Image:1ei3.jpg|left|200px]]<br /><applet load="1ei3" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ei3, resolution 5.5&Aring;" />
'''CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN'''<br />


==Overview==
==CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN==
The crystal structure of native chicken fibrinogen has been determined at, a resolution of 5.5 A. The full-length molecule is 460 A in length and, sigmoidally shaped. The structure includes the full sweep of the coiled, coils that connect the central and terminal domains; the chain paths of, the central domain confirm a predicted scheme of planar disulfide rings in, apposition with each other. Electron density maps have revealed the, outlines of disordered alphaC domains nestled within the confines of the, sinuous coiled coils. The amino-terminal segments of the alpha- and, beta-chains, including the fibrinopeptides A and B, are also disordered.
<StructureSection load='1ei3' size='340' side='right'caption='[[1ei3]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ei3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EI3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ei3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ei3 OCA], [https://pdbe.org/1ei3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ei3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ei3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ei3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIBA_CHICK FIBA_CHICK] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ei/1ei3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ei3 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1EI3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EI3 OCA].
*[[Fibrinogen|Fibrinogen]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of native chicken fibrinogen at 5.5-A resolution., Yang Z, Mochalkin I, Veerapandian L, Riley M, Doolittle RF, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3907-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10737772 10737772]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Doolittle, R.F.]]
[[Category: Doolittle RF]]
[[Category: Mochalkin, I.]]
[[Category: Mochalkin I]]
[[Category: Riley, M.]]
[[Category: Riley M]]
[[Category: Veerapandian, L.]]
[[Category: Veerapandian L]]
[[Category: Yang, Z.]]
[[Category: Yang Z]]
[[Category: coiled coils]]
[[Category: disulfide rings]]
[[Category: fibrin forming entities]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:00:53 2007''

Latest revision as of 07:03, 7 February 2024

CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN

1ei3, resolution 5.50Å

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