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New page: left|200px<br /><applet load="1ej6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ej6, resolution 3.6Å" /> '''Reovirus core'''<br /...
 
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[[Image:1ej6.gif|left|200px]]<br /><applet load="1ej6" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ej6, resolution 3.6&Aring;" />
'''Reovirus core'''<br />


==Overview==
==Reovirus core==
The reovirus core is an assembly with a relative molecular mass of 52, million that synthesizes, modifies and exports viral messenger RNA., Analysis of its structure by X-ray crystallography shows that there are, alternative, specific and completely non-equivalent contacts made by, several surfaces of two of its proteins; that the RNA capping and export, apparatus is a hollow cylinder, which probably sequesters its substrate to, ensure completion of the capping reactions; that the genomic, double-stranded RNA is coiled into concentric layers within the particle;, and that there is a protein shell that appears to be common to all groups, of double-stranded RNA viruses.
<SX load='1ej6' size='340' side='right' viewer='molstar' caption='[[1ej6]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ej6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJ6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ej6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ej6 OCA], [https://pdbe.org/1ej6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ej6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ej6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ej6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LMBD2_REOVD LMBD2_REOVD] Outer capsid protein involved in mRNA capping. Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ej6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ej6 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1EJ6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EJ6 OCA].
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
__TOC__
==Reference==
</SX>
Structure of the reovirus core at 3.6 A resolution., Reinisch KM, Nibert ML, Harrison SC, Nature. 2000 Apr 27;404(6781):960-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10801118 10801118]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Reovirus sp]]
[[Category: Reovirus sp.]]
[[Category: Harrison SC]]
[[Category: Harrison, S.C.]]
[[Category: Nibert ML]]
[[Category: Nibert, M.L.]]
[[Category: Reinisch KM]]
[[Category: Reinisch, K.M.]]
[[Category: ZN]]
[[Category: dsrna virus]]
[[Category: guanylyltransferase]]
[[Category: icosahedral]]
[[Category: icosahedral virus]]
[[Category: methylase]]
[[Category: methyltransferase]]
[[Category: non-equivalence]]
[[Category: virus]]
[[Category: zinc finger]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:02:44 2007''
Retrieved from "https://proteopedia.org/1ej6"