1c8v: Difference between revisions

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{{Seed}}
[[Image:1c8v.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID==
The line below this paragraph, containing "STRUCTURE_1c8v", creates the "Structure Box" on the page.
<StructureSection load='1c8v' size='340' side='right'caption='[[1c8v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1c8v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C8V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HE1:4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC+ACID'>HE1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
{{STRUCTURE_1c8v| PDB=1c8v |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8v OCA], [https://pdbe.org/1c8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c8v RCSB], [https://www.ebi.ac.uk/pdbsum/1c8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c8v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/1c8v_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c8v ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID===
==See Also==
 
*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10504236}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 10504236 is the PubMed ID number.
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-->
[[Category: Anderson KS]]
{{ABSTRACT_PUBMED_10504236}}
[[Category: Dealwis C]]
 
[[Category: Liang PH]]
==About this Structure==
[[Category: Lolis E]]
1C8V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8V OCA].
[[Category: Lubetsky JB]]
 
[[Category: Sachpatzidis A]]
==Reference==
Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase., Sachpatzidis A, Dealwis C, Lubetsky JB, Liang PH, Anderson KS, Lolis E, Biochemistry. 1999 Sep 28;38(39):12665-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10504236 10504236]
[[Category: Protein complex]]
[[Category: Salmonella typhimurium]]
[[Category: Tryptophan synthase]]
[[Category: Anderson, K S.]]
[[Category: Dealwis, C.]]
[[Category: Liang, P H.]]
[[Category: Lolis, E.]]
[[Category: Lubetsky, J B.]]
[[Category: Sachpatzidis, A.]]
[[Category: 8-fold alpha-beta barrel]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Lyase]]
 
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Retrieved from "https://proteopedia.org/1c8v"