1ci7: Difference between revisions

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{{Seed}}
[[Image:1ci7.png|left|200px]]


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==TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII==
The line below this paragraph, containing "STRUCTURE_1ci7", creates the "Structure Box" on the page.
<StructureSection load='1ci7' size='340' side='right'caption='[[1ci7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ci7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
{{STRUCTURE_1ci7|  PDB=1ci7 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci7 OCA], [https://pdbe.org/1ci7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_PNECA TYSY_PNECA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1ci7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ci7 ConSurf].
<div style="clear:both"></div>


===TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10529228}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 10529228 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_10529228}}
 
==About this Structure==
1CI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI7 OCA].
 
==Reference==
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits., Anderson AC, O'Neil RH, DeLano WL, Stroud RM, Biochemistry. 1999 Oct 19;38(42):13829-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10529228 10529228]
[[Category: Pneumocystis carinii]]
[[Category: Pneumocystis carinii]]
[[Category: Single protein]]
[[Category: Anderson AC]]
[[Category: Thymidylate synthase]]
[[Category: Delano WL]]
[[Category: Anderson, A C.]]
[[Category: O'Neil RH]]
[[Category: Delano, W L.]]
[[Category: Stroud RM]]
[[Category: Neil, R H.O.]]
[[Category: Stroud, R M.]]
[[Category: Half-sites reactivity]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:46:42 2008''
Retrieved from "https://proteopedia.org/1ci7"