1cn0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1cn0.png|left|200px]]


<!--
==CRYSTAL STRUCTURE OF D(ACCCT)==
The line below this paragraph, containing "STRUCTURE_1cn0", creates the "Structure Box" on the page.
<StructureSection load='1cn0' size='340' side='right'caption='[[1cn0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1cn0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CN0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cn0 OCA], [https://pdbe.org/1cn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1cn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cn0 ProSAT]</span></td></tr>
{{STRUCTURE_1cn0|  PDB=1cn0  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of d(ACCCT), solved by molecular replacement, shows a four-stranded i-motif conformation, where two parallel duplexes intercalate with one another in opposite orientations. Each duplex is stabilized by hemi-protonated C-C+ base pairing between parallel strands, and a string of water molecules bridge the cytosine N4 atoms to phosphate O atoms. This structure of d(ACCCT) shows examples of reversed Hoogsteen and Watson-Crick base pairing in both intermolecular and intramolecular manners to stabilize the tetraplex. Noticeably, the four-stranded complex is further stabilized at one end by a three-base hydrogen-bonding network, in which two adenines and a thymine form four hydrogen bonds via a reverse Hoogsteen and an asymmetric adenine-adenine base pairing. The structure of d(ACCCT) shows a similar local structure to that found in the d(TAA) part of the crystal structure of d(TAACCC) and provides further structural evidence that these base arrangements are essential for stabilizing these novel DNA super-secondary structures.


===CRYSTAL STRUCTURE OF D(ACCCT)===
Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT).,Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:10089350<ref>PMID:10089350</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_10089350}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1cn0" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 10089350 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_10089350}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CN0 OCA].
[[Category: Large Structures]]
 
[[Category: Cheng Y]]
==Reference==
[[Category: Kang C]]
Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT)., Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089350 10089350]
[[Category: Min T]]
[[Category: Cheng, Y.]]
[[Category: Sinha N]]
[[Category: Kang, C.]]
[[Category: Sutherland C]]
[[Category: Min, T.]]
[[Category: Wang S]]
[[Category: Sinha, N.]]
[[Category: Weil J]]
[[Category: Sutherland, C.]]
[[Category: Wang, S.]]
[[Category: Weil, J.]]
[[Category: I-motif]]
[[Category: Telomere]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:58:18 2008''
Retrieved from "https://proteopedia.org/1cn0"