1coa: Difference between revisions

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{{Seed}}
[[Image:1coa.png|left|200px]]


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==THE EFFECT OF CAVITY CREATING MUTATIONS IN THE HYDROPHOBIC CORE OF CHYMOTRYPSIN INHIBITOR 2==
The line below this paragraph, containing "STRUCTURE_1coa", creates the "Structure Box" on the page.
<StructureSection load='1coa' size='340' side='right'caption='[[1coa]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1coa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coa OCA], [https://pdbe.org/1coa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coa RCSB], [https://www.ebi.ac.uk/pdbsum/1coa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coa ProSAT]</span></td></tr>
{{STRUCTURE_1coa|  PDB=1coa |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ICI2_HORVU ICI2_HORVU] Inhibits both subtilisin and chymotrypsin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1coa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1coa ConSurf].
<div style="clear:both"></div>


===THE EFFECT OF CAVITY CREATING MUTATIONS IN THE HYDROPHOBIC CORE OF CHYMOTRYPSIN INHIBITOR 2===
==See Also==
 
*[[Chymotrypsin inhibitor 3D structures|Chymotrypsin inhibitor 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_8218191}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8218191 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8218191}}
 
==About this Structure==
1COA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COA OCA].
 
==Reference==
Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2., Jackson SE, Moracci M, elMasry N, Johnson CM, Fersht AR, Biochemistry. 1993 Oct 26;32(42):11259-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8218191 8218191]
[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Elmasry, N.]]
[[Category: Elmasry N]]
[[Category: Fersht, A R.]]
[[Category: Fersht AR]]
[[Category: Jackson, S E.]]
[[Category: Jackson SE]]
[[Category: Johnson, C M.]]
[[Category: Johnson CM]]
[[Category: Moracci, M.]]
[[Category: Moracci M]]
[[Category: Serine protease inhibitor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:00:53 2008''
Retrieved from "https://proteopedia.org/1coa"