1cq0: Difference between revisions

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{{Seed}}
[[Image:1cq0.png|left|200px]]


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==SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B '==
The line below this paragraph, containing "STRUCTURE_1cq0", creates the "Structure Box" on the page.
<StructureSection load='1cq0' size='340' side='right'caption='[[1cq0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1cq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CQ0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cq0 OCA], [https://pdbe.org/1cq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1cq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cq0 ProSAT]</span></td></tr>
{{STRUCTURE_1cq0|  PDB=1cq0  |  SCENE=  }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN] Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:[https://omim.org/entry/161400 161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.<ref>PMID:10973318</ref>
== Function ==
[https://www.uniprot.org/uniprot/OREX_HUMAN OREX_HUMAN] Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.


===SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B'SOLUTION STRUCTURE OF A HUMAN HYPOCRETIN-2/OREXIN-B '===
==See Also==
 
*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
 
== References ==
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{{ABSTRACT_PUBMED_10583376}}
 
==About this Structure==
1CQ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ0 OCA].
 
==Reference==
Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B., Lee JH, Bang E, Chae KJ, Kim JY, Lee DW, Lee W, Eur J Biochem. 1999 Dec;266(3):831-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10583376 10583376]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bang, E J.]]
[[Category: Bang EJ]]
[[Category: Chae, K J.]]
[[Category: Chae K-J]]
[[Category: Lee, D W.]]
[[Category: Lee DW]]
[[Category: Lee, K H.]]
[[Category: Lee K-H]]
[[Category: Lee, W.]]
[[Category: Lee W]]
[[Category: Human hcrt-2/ox-b,neuropeptide]]
[[Category: Nmr]]
[[Category: Obesity]]
[[Category: Solution structure]]
 
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Retrieved from "https://proteopedia.org/1cq0"