1dfa: Difference between revisions

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{{Seed}}
[[Image:1dfa.png|left|200px]]


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==CRYSTAL STRUCTURE OF PI-SCEI IN C2 SPACE GROUP==
The line below this paragraph, containing "STRUCTURE_1dfa", creates the "Structure Box" on the page.
<StructureSection load='1dfa' size='340' side='right'caption='[[1dfa]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfa OCA], [https://pdbe.org/1dfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfa RCSB], [https://www.ebi.ac.uk/pdbsum/1dfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfa ProSAT]</span></td></tr>
{{STRUCTURE_1dfa| PDB=1dfa |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/VATA_YEAST VATA_YEAST] Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase (vacuolar ATPase) is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mV, inside positive and acidic, in the vacuolar membrane vesicles. It may participate in maintenance of cytoplasmic Ca(2+) homeostasis. This is a catalytic subunit.<ref>PMID:1534148</ref>  PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates "homing", a genetic event that converts a VMA1 allele lacking VDE into one that contains it.<ref>PMID:1534148</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfa ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF PI-SCEI IN C2 SPACE GROUP===
==See Also==
 
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 10644733 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_10644733}}
 
==About this Structure==
1DFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFA OCA].
 
==Reference==
Probing the structure of the PI-SceI-DNA complex by affinity cleavage and affinity photocross-linking., Hu D, Crist M, Duan X, Quiocho FA, Gimble FS, J Biol Chem. 2000 Jan 28;275(4):2705-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10644733 10644733]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Crist M]]
[[Category: Crist, M.]]
[[Category: Duan X]]
[[Category: Duan, X.]]
[[Category: Gimble FS]]
[[Category: Gimble, F S.]]
[[Category: Hu D]]
[[Category: Hu, D.]]
[[Category: Quiocho FA]]
[[Category: Quiocho, F A.]]
[[Category: Homing endonuclease]]
[[Category: Hydrolase]]
[[Category: Intein]]
 
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Retrieved from "https://proteopedia.org/1dfa"